Answer:
What goes up but never comes down?
Without a bridle, or a saddle, across a thing I ride a-straddle. And those I ride, by help of me, though almost blind, are made to see.
Slayer of regrets, old and new, sought by many, found by few.
Describes universities like Harvard and can be poisonous.
Though not a plant, has leaves. Though not a beast, has spine. Though many wouldn't need this thing, It's more valuable than wine.
An open ended barrel, it is shaped like a hive. It is filled with the flesh, and the flesh is alive!